(Solved): The graph below represents the adult hemoglobin binding curve at \( \mathrm{pH} 7.4 \) in the prese ...

The graph below represents the adult hemoglobin binding curve at \( \mathrm{pH} 7.4 \) in the presence of \( 2,3 \mathrm{BPG}(2,3 \) Bisphosphoglycerate). The hemoglobin binding curve has a sigmoidal shape, due to 4 interacting oxygen-bound sites. For comparison, the myoglobin curve has only one oxygen bound site and has a hyperbolic curve. Below are list of 4 scenarios. For each scenario determine whether the hemoglobin binding curve will shift to the right (meaning lower O2 affinity) OR to the left (meaning higher \( \mathrm{O} 2 \) affinity). Explain your reasoning for each scenario and where necessary state if and how the scenario impacts either the \( T \) or \( R \) state of hemogiobin. A) The \( \mathrm{CO}_{2} \) concentration in blood increases [2 marks] B) Tetrameric hemoglobin is dissociated into its subunits [2 marks] C) Hemoglobin is isolated from red blood cells and stripped of 2,3BPG [ 2 marks] D) The blood \( \mathrm{pH} \) drops from \( 7.4 \) to \( 7.2 \) [2 marks]