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(Solved): pls help. predict the major products for the following reaction Introduction: The synthesis of ...



pls help. predict the major products for the following reaction


Introduction:
The synthesis of organic molecules often involves stringing together more than one reaction into a multistep sy
Introduction: The synthesis of organic molecules often involves stringing together more than one reaction into a multistep synthesis. Although this is often necessary to synthesize a target molecule, a large disadvantage of multistep synthesis is the loss of yield at each step, often leading to a low overall percent yield. In today's experiment, you will perform a three-step synthesis that aims to achieve a high overall experimental yield by conducting three reactions consecutively in the same reaction vessel, thus minimizing the loss of product. The first two steps in this sequence are together known as a reductive amination. Reductive amination is a method used to synthesize an amine by reacting an aldehyde or a ketone with a \( 1^{\circ} \) or \( 2^{\circ} \) amine in acidic conditions to first form an imine or enamine, and then reduce that imine or enamine to the amine (Scheme 1). Scheme 1. An example of a two-step reductive amination. In this experiment, we will be using sodium borohydride \( \left(\mathrm{NaBH}_{4}\right) \) as the source of nucleophilic hydride for the reduction of the imine to the amine. The reducing agent must be added after the imine formation is complete, otherwise it would simply reduce the starting aldehyde to an alcohol before it could react to form the imine. If a hydride donor that is weaker than \( \mathrm{NaBH}_{4} \), such as sodium cyanoborohydride \( \left(\mathrm{NaBH}_{3} \mathrm{CN}\right) \) were used instead, then all reagents could be added at the same time in a one-step reductive amination (Scheme 2). Scheme 2. An example of a one-pot reductive amination reaction.


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