(Solved): Pladienolide B is a macrocyclic (large ring) natural product isolated from an engineered strain of ...

Pladienolide B is a macrocyclic (large ring) natural product isolated from an engineered strain of the bacterium Streptomyces platensis. a. Label each disubstituted \( \pi \) bond as the cis or trans configuration. b. Label each tri-or tetrasubstituted \( \pi \) bond as the \( E \) or \( Z \) configuration. c. How many total stereoisomers are possible for pladienolide B? Hint: don't forget to consider both alkene configurations and \( s p^{3} \) chiral carbons! d. Draw the enantiomer of pladienolide \( \mathbf{B} \). e. Draw the diastereomer of pladienolide \( B \) in which every \( \pi \) bond is in the cis or \( Z \) configuration