A 54-year-old man presents to the ED because of loss of consciousness at work. He reported feeling dizzy and light-headed just before becoming unconscious. The patient's wife states that this episode occurred approximately 30 minutes prior to his arrival at the hospital. His past medical history is significant for poorly controlled hypertension and type 2 diabetes mellitus. His pulse is 48/min, respiratory rate 12/min, and blood pressure 90/50 mm Hg. The patient did not regain consciousness and died 6 hours after arriving at the hospital, after he was diagnosed with an acute ST-elevation myocardial infarction (STEMI) involving the anterior myocardial wall. At autopsy, a fresh thrombus was found completely occluding the left anterior descending artery of the heart. In the brain, there were areas of necrosis identified histologically in the medial portions of the temporal lobes. Which of the following structures is most likely to have undergone necrosis in the brain? A. Hippocampus B. Caudate nucleus C. Cortex or cerebral hemisphere D. Frontal lobe E. Substantia nigra