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(Solved): Draw the mechanism for the reaction catalyzed by acetylCoA acetyl transferase using curved double ...



Draw the mechanism for the reaction catalyzed by acetyl?CoA acetyl transferase using curved double?barbed arrows to show the movement of electrons.Draw a mechanism for each of the three reactions shown in
the figure, detailing the pathway for the synthesis of
mevalonate f|8_5__
HMG-CoA
reductase
COO-
CH,
CH?-C-OH
CH?
S-COA
2 NADPH + 2H+
2NADP+
CoA-SH
Coo-
B-Hydroxy-3-methylglutaryl-CoA
(HMG-CoAO
I
CH3
E
I
S
S-COA
H +
CoA-SH
Enz
CH 3Enz
CH3
COA-S
-CH?
E
HY
COA
CH3
B
|
E
S-COA
H?
CH3||
S-COA
H*
H?
O=
H-
||
- C- CH3
|
H
E
|
E
Enz
CH?
H?C-C
O=C
S
I
COA
CH?
H?O
- ??
BH
Enz
:0
CH?
H?C-C-OH
CH?2
O=C
C1S
Enz
I
CH C
?
I
CH?
I
|
CH?
I
= c
I
S-CoA
- OH
c1c
? ?
I
R
||
||
NH?
CoA-SH + NAD+
CH?
HC-?
- ??
CH?
0=? - ?H.C
?
I
CH?
I
- C - ??
I
CH?
I
? - ?
||
? ?
D-z:
II
NH?
NAD+
CH2
HC-C
??
CH2
?— ? — ?
I
??

Draw a mechanism for each of the three reactions shown in the figure, detailing the pathway for the synthesis of mevalonate from acetyl-CoA. 2 CH?- S-COA Acetyl-CoA CoA-SH acetyl-CoA acetyl transferase O CH?-C-CH?-C² HMG-CoA synthase S-COA Acetoacetyl-CoA S-COA CH?-C CoA-SH |8_5__ HMG-CoA reductase COO- CH, CH?-C-OH CH? S-COA 2 NADPH + 2H+ 2NADP+ CoA-SH Coo- B-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) I 2CH? CH, ³C-OH 4 CH? _T 5 ??, ?? Mevalonate O I CH3 E I S S-COA H + CoA-SH Enz CH 3 Enz CH3 COA-S -CH? E HY COA CH3 B | E S-COA H? CH3 || S-COA H* H? O= H- || - C- CH3 | H E | E Enz CH? H?C-C O=C S I COA CH? H?O - ?? BH Enz :0 CH? H?C-C-OH CH?2 O=C C1S Enz I COA SH H C ? I CH? I | CH? I = c I S-CoA - OH c1c ? ? I R || || NH? CoA-SH + NAD+ CH? HC-? - ?? CH? 0=? - ? H.C ? I CH? I - C - ?? I CH? I ? - ? || ? ? D-z: II NH? NAD+ CH2 HC-C ?? CH2 ?— ? — ? I ??


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