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(Solved): Draw the mechanism for the reaction catalyzed by acetylCoA
acetyl transferase using curved double ...
Draw the mechanism for the reaction catalyzed by acetyl?CoA
acetyl transferase using curved double?barbed arrows to show the
movement of electrons.
Draw a mechanism for each of the three reactions shown in the figure, detailing the pathway for the synthesis of mevalonate from acetyl-CoA. 2 CH?- S-COA Acetyl-CoA CoA-SH acetyl-CoA acetyl transferase O CH?-C-CH?-C² HMG-CoA synthase S-COA Acetoacetyl-CoA S-COA CH?-C CoA-SH
|8_5__ HMG-CoA reductase COO- CH, CH?-C-OH CH? S-COA 2 NADPH + 2H+ 2NADP+ CoA-SH Coo- B-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) I 2CH? CH, ³C-OH 4 CH? _T 5 ??, ?? Mevalonate
O I CH3 E I S S-COA H + CoA-SH Enz CH 3
Enz CH3 COA-S -CH? E HY COA CH3 B | E S-COA H? CH3
|| S-COA H* H? O= H- || - C- CH3 | H E | E Enz CH? H?C-C O=C S I COA CH? H?O - ?? BH Enz :0 CH? H?C-C-OH CH?2 O=C C1S Enz I COA SH
H C ? I CH? I | CH? I = c I S-CoA - OH c1c ? ? I R || || NH? CoA-SH + NAD+ CH? HC-? - ?? CH? 0=? - ?
H.C ? I CH? I - C - ?? I CH? I ? - ? || ? ? D-z: II NH? NAD+ CH2 HC-C ?? CH2 ?— ? — ? I ??