(Solved): Blood Flow Figure 1: Chamber plethysmograph for measuring blood flow limitation in the leg. 1. The ...

Blood Flow Figure 1: Chamber plethysmograph for measuring blood flow limitation in the leg. 1. The chamber plethysmograph shown in Figure 1 is used to measure blood flow in the leg. At the beginning of the experiment, the leg is placed in a chamber and both cuffs are inflated so that blood volume aceumulates in the calf with every consecutive heart beat. By assessing how rapidly the blood volume is removed from the calf once the pressure in the venous occlusion cuff is removed, flow limitation can be detected to diagnose deep vein thrombosis, for example. The chamber has a volume of $200\mathrm{ml}$ that is completely occupied by leg tissue before venous ocelusion pressure is released from the cuff. Volume changes are indirectly measured by the device through a pressure transducer, assuming an adiabatic process, i.e. $P(V{)}^{1.4}=$ constant. Assume that the pressure in the chamber at the beginning of the experiment is 1 atmosphere. Calculate the rapid change in tissue volume in the chamber that produces a $120\mathrm{Pa}$ change in chamber pressure.