(Solved): A certain transcription factor protein has a DNA-binding domain and a dimerization domain that allo ...

A certain transcription factor protein has a DNA-binding domain and a dimerization domain that allows it associate with other copies of itself. This transcription factor is only able to stably bind DNA when two DNA-binding domains are present (that is, it requires dimerization). What effect do you expect to observe in an organism that is heterozygous for a wildtype allele of the transcription factor gene and a mutant allele that lacks the DNA-binding domain? mutant phenotype that looks similar to a complete loss of the wildtype alleles mutant phenotype that looks similar to overexpression of the wildtype allele lethality wildtype phenotype The following pedigree shows inheritance of a rare autosomal dominant disorder. If the disease has \( 60 \% \) penetrance, what is the probability that a child of II- 4 and II-5 will be inherit the dominant allele? (Assume that II-2 and II-5 are not carriers of the dominant allele) \( 0 \% \) \( 20 \% \) \( 10 \% \) \( 25 \% \) \( 50 \% \)